powerful science

Supercharged TCRs

living cancer free

Developing supercharged T cell therapies

We are focused on T cell receptor engineered T cell therapies, TCR-Ts, a promising modality that holds the potential to generate transformational responses in patients with solid tumors. By armoring T cells with the most advanced enhancements in a single T cell, T-knife is designing T cell therapies to achieve a clinically meaningful impact for patients.

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Discovering novel, high affinity and high specificity, human TCRs targeting the most immunogenic epitopes

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Engineering T cells with tailored, best-in-class enhancements to create supercharged TCR-Ts

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Building a pipeline of TCR-Ts designed to improve response rates and durability in solid tumor cancers

Our Science

Advancing portfolio of TCR therapies for solid tumors

Through the use of natural, fully human TCRs and tailored armoring, T-knife’s product candidates are designed to induce an organically optimized immune signaling cascade intended to stimulate a potent T cell-driven immune response. Our TCR therapies target tumor antigens in multiple, difficult to treat solid tumor indications.

Our Pipeline