powerful science

About T-knife

T-knife Therapeutics is a biopharmaceutical company dedicated to developing novel therapeutics to fight cancer. The company is initially focused on T cell receptor (TCR) engineered T cell therapies (TCR-Ts), a promising modality that holds the potential to generate transformative responses in patients with solid tumors. The company’s unique approach is based on combining the most advanced, internally-developed, T cell enhancements to create supercharged TCR-Ts designed to achieve deeper responses and durability in solid tumor cancers. 

T-knife’s differentiation starts with the proprietary MyT™ platform, a next-generation T cell receptor and epitope discovery engine that produces fully human, tumor-specific TCRs, naturally selected in vivo for optimal affinity and high specificity.

T-knife has also discovered novel, potentially best-in-class CD8 coreceptors and switch receptors, designed to enhance T cell fitness and persistence and overcome the immunosuppressive tumor microenvironment. All of these technologies are then engineered into human T cells, or TCR-Ts.

T-knife’s discovery engine has generated a pipeline of TCR-T product candidates against several tumor targets that are expressed in indications with high unmet medical need. T-knife was founded by leading T-cell and immunology experts using technology developed at the Max Delbruck Center for Molecular Medicine together with Charité – Universitätsmedizin Berlin.



Photo of Dr. Elisa Kieback

Elisa Kieback, Ph.D.
Chief Technology Officer

Photo of Camille Landis

Camille Landis
Chief Business Officer / Chief Financial Officer

Photo of Simone Silva Steiner

Simone Silva Steiner, Ph.D.
Chief Technical Operations Officer

Photo of Thomas Soloway

Thomas Soloway
Chief Executive Officer

Photo of Dr. Peggy Sotiropoulou

Peggy Sotiropoulou, Ph.D.
Chief Scientific Officer

Board of Directors

Photo of Alexander Mayweg

Alexander Mayweg, Ph.D.
Versant Ventures

Photo of Thomas Blankenstein

Thomas Blankenstein, Ph.D.
Scientific Founder of T-knife

Photo of Laura-Brege

Laura Brege
Independent Board Member

Photo of geraldine okeeffe

Geraldine O'Keeffe
EQT Life Sciences

Photo of Olivier Litzka

Olivier Litzka, Ph.D.
Andera Partners

Photo of Josh Resnick

Josh Resnick, M.D.
RA Capital Management

Photo of Debasish Roychowdhury

Debasish Roychowdhury, M.D.
Independent Board Member

Photo of Thomas Soloway

Thomas Soloway
Chief Executive Officer